Potassium cyanate → HCID 87099630, compound

HRID 709155Notes

Reaction equation

Cl.[NH2:2][CH:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:30]=1[Cl:36])[CH2:4][NH:5][C:6](=[O:28])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)=[N:9]1.[O-:37][C:38]#[N:39].[K+]>>[C:38]([NH:2][CH:3]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:30]=1[Cl:36])[CH2:4][NH:5][C:6](=[O:28])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:17])[F:19])[C:10]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)=[N:9]1)(=[O:37])[NH2:39]

Participants

Reactant 2

HCID 11378442Potassium cyanate

HCID 89764468HCID 89764468, compound

Product 1

HCID 87099630HCID 87099630, compound

Procedure

Analogously to Example 23, 30 mg (51 μmol) of the compound of Example 55A and potassium cyanate gave 19 mg (63% of theory) of the title compound.

Sources & evidence

ORD record: ord-c7fa770741fa4555865562170d2fa469
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180120B2

Reaction notes

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