[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid → 2-(2-Chlorophenyl)-3-({[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)propyl carbamate

Participants

Role	Name	HCID	Charge
Reactant	[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid	HCID 58012119	—
Reactant	3-Amino-2-(2-chlorophenyl)propyl carbamate	HCID 68032415	—
Product	2-(2-Chlorophenyl)-3-({[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetyl}amino)propyl carbamate	HCID 66635551	—

Reaction Steps

Analogously to the procedure of Example 63, 49 mg (135 μmol) of [3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetic acid [for the preparation see Example 156A in WO 2007/134862] were reacted with 34 mg (149 μmol) of the compound of Example 15A. This gave 27 mg (35% of theory) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09180120B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-7ffb5bacabef4b429e1e62aec9b41932
Source note	uspto-grants-2015_11