Methanesulfonyl chloride → HCID 66611597, compound

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Reaction Steps

At RT, 4.1 μl of methanesulphonyl chloride were added to a solution of 29 mg (48 μmol) of the compound of Example 59A in 0.5 ml of pyridine. The mixture was stirred at RT for 1 h, and another 4.1 ml of methanesulphonyl chloride were added. The mixture was stirred at RT for another 18 h, and another 12.3 μl of methanesulphonyl chloride were added over a period of 3 h (265 μmol, 5.5 eq., in total). After 1 h, the volatile components were removed on a rotary evaporator. The residue was dissolved in a little DMSO and purified by preparative HPLC [Method 9]. This gave 17 mg (65% of theory) of the title compound.

Provenance & Evidence