Methanesulfonyl chloride → HCID 66610966, compound

HRID 709171Notes

Reaction equation

Cl.[NH2:2][CH:3]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([F:38])([F:37])[F:36])[CH2:4][NH:5][C:6](=[O:28])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[C:10]([C:22]2[S:23][C:24]([Cl:27])=[CH:25][CH:26]=2)=[N:9]1.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>>[Cl:27][C:24]1[S:23][C:22]([C:10]2[N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([NH:2][S:40]([CH3:39])(=[O:42])=[O:41])[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]([F:36])([F:37])[F:38])=[O:28])[N:9]=2)=[CH:26][CH:25]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 87073864HCID 87073864, compound

Product 1

HCID 66610966HCID 66610966, compound

Procedure

Analogously to the procedure of Example 68, 35 mg (52 μmol) of the compound of Example 61A were reacted with methanesulphonyl chloride. This gave 14 mg (41% of theory) of the title compound.

Sources & evidence

ORD record: ord-61b3a71dfac8408d81ef5146f34cec97
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09180120B2

Reaction notes

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