Water → 3-Benzyloxy-4-methylbenzoic acid benzyl ester

Participants

Reaction Steps

To a mixture of 3-hydroxy-4-methylbenzoic acid (2.00 g) and potassium carbonate (5.40 g) in DMF (20 mL) was added dropwise benzyl bromide (4.50 g) at room temperature, and the mixture was stirred for 3 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (4.30 g) as a colorless oil. This compound was used for the next step without further purification.

Provenance & Evidence