反应详情

To a solution of 6-(chloromethyl)-2-(2,2-dimethylpropyl)-3-(2-fluoro-5-methoxyphenyl)pyridine (320 mg) in acetonitrile (30 mL) were added methyl 3-cyclopropyl-3-(4-fluoro-3-hydroxyphenyl)propanoate (220 mg) and cesium carbonate (550 mg), and the mixture was heated under reflux for 15 hr. The reaction mixture was concentrated, and water was added to the residue. The mixture was extracted with ethyl acetate, and the extract was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (400 mg) as a yellow oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 15 hr
3. concentrationThe reaction mixture was concentrated
4. additionwater was added to the residue
5. extractionThe mixture was extracted with ethyl acetate
6. washthe extract was washed with saturated brine
7. dry with materialThe organic layer was dried over anhydrous sodium sulfate
8. customthe solvent was evaporated under reduced pressure
9. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)