Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl 3-(3-(benzyloxy)-5-methoxyphenyl)acrylate

Participants

Reaction Steps

To a solution of 3-(benzyloxy)-5-methoxybenzaldehyde (5.50 g) in toluene (50 mL) was added ethyl (triphenylphosphoranylidene)acetate (7.90 g), and the mixture was heated under reflux for 4 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (6.00 g) as a colorless oil.

Provenance & Evidence