HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 709681Generated: October 30, 2026
Methyl Acrylate → Methyl 3-(3-(benzyloxy)-5-fluorophenyl)acrylate
https://huagongshe.com/reaction/709681
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-(Benzyloxy)-3-bromo-5-fluorobenzene | HCID 11254516 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 3-(3-(benzyloxy)-5-fluorophenyl)acrylate | HCID 131733901 | — |
Reaction Steps
To a solution of 1-(benzyloxy)-3-bromo-5-fluorobenzene (6.60 g) in acetonitrile (130 mL) were added methyl acrylate (13.7 g), triphenylphosphine (3.36 g) and triethylamine (14.5 g), and toluene (2.0 mL) and palladium acetate (480 mg) were further added. The reaction mixture was stirred at 100° C. for 96 hr, and the solvent was evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09181186B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-62617ea181ec4e649af81bb8498b222d |
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| Source note | uspto-grants-2015_11 |
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