Methyl 3-(3-(benzyloxy)-5-fluorophenyl)acrylate → Methyl 3-(3-fluoro-5-hydroxyphenyl)propanoate

Participants

Reaction Steps

To a solution of methyl 3-(3-(benzyloxy)-5-fluorophenyl)acrylate (2.60 g) in methanol (15 mL) was added 10% palladium-activated carbon (2.20 g), and the mixture was stirred for 1 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (710 mg) as a white solid.

Provenance & Evidence