HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(5-(benzyloxy)-2-methylphenyl)acrylate → Ethyl 3-(5-hydroxy-2-methylphenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(5-(benzyloxy)-2-methylphenyl)acrylate | HCID 131733902 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 3-(5-hydroxy-2-methylphenyl)propanoate | HCID 117759938 | 71.2% |
Reaction Steps
To a solution of ethyl 3-(5-(benzyloxy)-2-methylphenyl)acrylate (1.00 g) in methanol (50 mL) was added 10% palladium-activated carbon (150 mg), and the mixture was stirred for 15 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (500 mg) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181186B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-fb54cab69ffc4a5b99a9865ee8761d76 |
| Source note | uspto-grants-2015_11 |