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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 709690Generated: October 29, 2026

Ethyl 3-(5-(benzyloxy)-2-methylphenyl)acrylate → Ethyl 3-(5-hydroxy-2-methylphenyl)propanoate

https://huagongshe.com/reaction/709690

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(5-(benzyloxy)-2-methylphenyl)acrylateHCID 131733902—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductEthyl 3-(5-hydroxy-2-methylphenyl)propanoateHCID 11775993871.2%

Reaction Steps

To a solution of ethyl 3-(5-(benzyloxy)-2-methylphenyl)acrylate (1.00 g) in methanol (50 mL) was added 10% palladium-activated carbon (150 mg), and the mixture was stirred for 15 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (500 mg) as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181186B2
Source datasetuspto-grants-2015_11
ORD IDord-fb54cab69ffc4a5b99a9865ee8761d76
Source noteuspto-grants-2015_11