反应详情

To a solution of sodium methoxide (227 mg) in methanol (10 ml) was added ethyl 3-(2-methoxy-5-(methoxycarbonyloxy)phenyl)propanoate (1.00 g), and the mixture was stirred for 1 hr. The reaction mixture was concentrated, and the residue was extracted with ethyl acetate. The extract was washed with saturated brine, and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (730 mg) as a yellow oil. This compound was used for the next step without further purification.

1. concentrationThe reaction mixture was concentrated
2. extractionthe residue was extracted with ethyl acetate
3. washThe extract was washed with saturated brine
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. customThe solvent was evaporated under reduced pressure