Ethyl 3-(2-fluoro-5-methoxyphenyl)acrylate → Ethyl 3-(2'-fluoro-5'-methoxyphenyl)propionate

Participants

Reaction Steps

To a solution of ethyl 3-(2-fluoro-5-methoxyphenyl)acrylate (224 mg) in ethanol (50 mL) was added 10% palladium-activated carbon (24 mg), and the mixture was stirred for 15 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (208 mg) as a colorless oil. This compound was used for the next step without further purification.

Provenance & Evidence