Boron tribromide → HCID 117759834, compound

Participants

Reaction Steps

To a solution of ethyl 3-(2-fluoro-3-methoxyphenyl)propanoate (2.50 g) in dichloromethane (50 mL) was added a 3.0 M solution of boron tribromide in dichloromethane (11 mL) at 0° C., and the mixture was stirred at room temperature for 15 hr. Ice water (100 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (2.20 g) as a solid. This compound was used for the next step without further purification.

Provenance & Evidence