HCID 131733908, compound → HCID 117760185, compound

Participants

Reaction Steps

To a solution of 3-(6-((6-(2,2-dimethylpropyl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl)methoxy)-2-methylpyrimidin-4-yl)acrylic acid (330 mg) in THF (5.0 mL) and ethyl acetate (5.0 mL) was added 10% palladium-activated carbon (30 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 2 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by preparative HPLC to give the title compound (153 mg) as a white solid.

Provenance & Evidence