Hydrochloric Acid → HCID 131733910, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (6-(2,2-dimethylpropyl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl)methanol (480 mg) and methyl 3-(6-chloro-2-methoxypyrimidin-4-yl)acrylate (360 mg) in THF (8.0 mL) was added 60% sodium hydride (128 mg) at 0° C., and the mixture was stirred at 50° C. for 2 hr. 1N Hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (520 mg) as a white solid.

Provenance & Evidence