反应详情

To a suspension of lithium aluminum hydride (622 mg) in diethyl ether (20 mL) was added a solution of methyl 6-(2-fluoro-5-methoxyphenyl)-5-isobutoxynicotinate (1.82 g) in diethyl ether (5.0 mL) at 0° C., and the mixture was stirred for 30 min. Water and aqueous sodium hydroxide solution were added to the reaction mixture, and the resulting precipitate was filtered off. The solvent in the filtrate was concentrated, and the residue was recrystallized (ethyl acetate/hexane) to give the title compound (1.30 g) as a white solid.

1. filtrationthe resulting precipitate was filtered off
2. concentrationThe solvent in the filtrate was concentrated
3. customthe residue was recrystallized (ethyl acetate/hexane)