Water → (6-(2-Fluoro-5-methoxyphenyl)-5-isobutoxy-2-methoxypyridin-3-yl)methanol

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (67 mg) in diethyl ether (2.0 mL) was added a solution of methyl 6-(2-fluoro-5-methoxyphenyl)-5-isobutoxy-2-methoxynicotinate (213 mg) in diethyl ether (1.0 mL) at 0° C., and the mixture was stirred for 20 min. Water and aqueous sodium hydroxide solution were added to the reaction mixture, and the resulting precipitate was filtered off. The solvent in the filtrate was evaporated to give a crude product of the title compound (1.30 g) as an orange oil. This compound was used for the next step without further purification.

Provenance & Evidence