Phosphorus tribromide → 5-(Bromomethyl)-2-(2-fluoro-5-methoxyphenyl)-3-neopentylpyridine

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, phosphorus tribromide (37 μL) was added to DMF (1.0 mL) at 0° C. and the mixture was stirred at 0° C. for 5 min. To the obtained white suspension was added (6-(2-fluoro-5-methoxyphenyl)-5-neopentylpyridin-3-yl)methanol (100 mg), and the mixture was stirred at room temperature for 30 min. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction solution at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a crude product of the title compound (88 mg) as a pale-yellow oil. This compound was used for the next step without further purification.

Provenance & Evidence