反应详情

A mixture of 5-(bromomethyl)-2-(2-fluoro-5-methoxyphenyl)-3-neopentylpyridine (88 mg), ethyl 3-cyclopropyl-3-(2-hydroxypyridin-4-yl)propanoate (62 mg), silver carbonate (72.6 mg) and toluene (2.0 mL) was heated under reflux for 3 hr. The reaction mixture was cooled to room temperature and filtered. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (28 mg) as an orange oil.

1. temperaturewas heated
2. temperatureunder reflux for 3 hr
3. filtrationfiltered
4. customThe solvent in the filtrate was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)