Sodium Hydroxide → 3-Cyclopropyl-3-(2-((5-(2,2-dimethylpropyl)-6-(2-fluoro-5-methoxyphenyl)pyridin-3-yl)methoxy)pyridin-4-yl)propanoic acid

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Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(2-((6-(2-fluoro-5-methoxyphenyl)-5-neopentylpyridin-3-yl)methoxy)pyridin-4-yl)propanoate (28 mg) in THF (1.0 mL) and methanol (0.50 ml) was added 1N aqueous sodium hydroxide solution (1.0 mL), and the mixture was stirred at room temperature for 1 hr. The solvent in the reaction mixture was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (21 mg) as a yellow amorphous solid.

Provenance & Evidence