Ethanol → HCID 117759857, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(2-fluoro-5-methoxyphenyl)-4-isobutoxypyrimidine-2-carbonitrile (1.00 g) in ethanol (25 mL) and water (8.3 mL) was added conc. sulfuric acid (25 mL) at 0° C., and the mixture was stirred at 120° C. for 1 hr. To the reaction mixture was added water at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (284 mg) as a pale-yellow oil.

Provenance & Evidence