Hydrochloric Acid → HCID 117759910, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, to a solution of (5-(2-fluoro-5-methoxyphenyl)-4-isobutoxypyrimidin-2-yl)methanol (111 mg) and ethyl 3-(6-chloropyrimidin-4-yl)-3-cyclopropylpropanoate (92 mg) in THF (2.0 mL) was added 60% sodium hydride (17 mg) at room temperature, and the mixture was stirred at 50° C. for 2 hr. To the reaction mixture was added 1N hydrochloric acid at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (111 mg) as a colorless oil.

Provenance & Evidence