Hydrochloric Acid → HCID 117760201, compound

Participants

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(6-((5-(2-fluoro-5-methoxyphenyl)-4-isobutoxypyrimidin-2-yl)methoxy)pyrimidin-4-yl)propanoate (111 mg) in THF (2.0 mL) and methanol (1.0 ml) was added 1N aqueous sodium hydroxide solution (2.0 mL), and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added 1N hydrochloric acid (2.0 mL) at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. After silica gel filtration, the solvent was evaporated under reduced pressure to give the title compound (105 mg) as a white amorphous solid.

Provenance & Evidence