HCID 131733920, compound → HCID 117760250, compound

Participants

Reaction Steps

To a solution of ethyl 3-cyclopropyl-3-(5-fluoro-2-methoxypyridin-4-yl)acrylate (entire amount) in acetic acid (100 mL) was added a zinc powder (50.2 g), and the mixture was stirred at room temperature for 30 min. The reaction mixture was filtered, and the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (5.72 g) as a colorless oil.

Provenance & Evidence