Ethyl Acetate → HCID 178471099, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, to a solution of ethyl 3-cyclopropyl-3-(5-fluoro-2-methoxypyridin-4-yl)propanoate (5.72 g) in DMF (10 ml) was added pyridinium chloride (24.7 g), and the mixture was stirred at 130° C. for 1 hr. To the reaction mixture was added ethyl acetate at 0° C., and the resulting precipitate was removed by filtration. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (4.29 g) as a colorless oil.

Provenance & Evidence