(5-(2-Fluoro-5-methoxyphenyl)-6-neopentylpyridin-2-yl)methanol → HCID 117760191, compound

Participants

Reaction Steps

Silver oxide (327 mg) was added to a solution of (6-(2,2-dimethylpropyl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl)methanol (415 mg) and ethyl 3-cyclopropyl-3-(5-fluoro-2-hydroxypyridin-4-yl)propanoate (300 mg) in toluene (5 mL) at room temperature, and the mixture was heated under reflux for 2 hr. The reaction mixture was filtered, and the solvent in the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (379 mg) as a pale-yellow oil.

Provenance & Evidence