Methanol → HCID 117760047, compound

Participants

Reaction Steps

To a mixture of methyl 5-(2-cyanoethyl)-6-(2-fluoro-5-methoxyphenyl)nicotinate (548 mg), methanol (2 mL) and THF (10 mL) was added sodium borohydride (208 mg), and the mixture was refluxed for 1 hr. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (425 mg) as a colorless oil.

Provenance & Evidence