Water → HCID 117760043, compound

Participants

Reaction Steps

To a solution of 1-((2-(2-fluoro-5-methoxyphenyl)-5-(hydroxymethyl)pyridin-3-yl)methyl)cyclopentanecarbonitrile (353 mg) and triphenylphosphine (410 mg) in toluene (10 mL) was added carbon tetrabromide (512 mg), and the mixture was stirred at room temperature for 3 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (339 mg) as white crystals.

Provenance & Evidence