Ethyl Acetate → HCID 178471099, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, to a solution of ethyl 3-cyclopropyl-3-(5-fluoro-2-methoxypyridin-4-yl)propanoate (1.38 g) obtained in step A in DMF (2.5 mL) was added pyridinium chloride (5.97 g), and the mixture was stirred at 130° C. for 2 hr. To the reaction mixture was added ethyl acetate at 0° C., and the resulting precipitate was removed by filtration. The solvent in the filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (1.65 g) as a pale-yellow oil.

Provenance & Evidence