Hydrogen Bromide → HCID 86267407, compound

Participants

Reaction Steps

Using the procedure of Example 1, N-ethyl-4-methoxy-5-(6-methyl-5-((2-(4-methyl-1H-imidazol-1-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-2-amine (0.12 g, 0.29 mmol) and 48% HBr (0.63 mL, 11.5 mmol) were combined to afford 2-(ethylamino)-5-(6-methyl-5-((2-(4-methyl-1H-imidazol-1-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one as a white solid (0.06 g, 51%). 1H NMR (400 MHz, DMSO-d6): δ 10.60 (br s, 1H), 8.68 (s, 1H), 8.40 (d, J=1.3 Hz, 1H), 8.31-8.30 (m, 2H), 7.64 (s, 1H), 7.54 (d, J=8.6 Hz, 1H), 7.39 (d, J=2.2 Hz, 1H), 6.93 (br s, 1H), 6.73 (dd, J=5.8, 2.2 Hz, 1H), 3.35-3.33 (m, 2H), 2.35 (s, 3H), 2.13 (s, 3H), 1.12 (t, J=7.1 Hz, 3H); MS (ESI) m/z: 404.2 (M+H+).

Provenance & Evidence