Hydrogen Bromide → HCID 86267410, compound

Participants

Reaction Steps

Using the procedure of Example 7, N-ethyl-4-methoxy-5-(5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-2-amine (0.080 g, 0.20 mmol) was combined with acetic acid (3 mL) and HBr (0.090 mL, 0.79 mmol) to afford 2-(ethylamino)-5-(5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one (40 mg, 51%). 1H NMR (400 MHz, DMSO-d6): δ 11.12 (s, 1H), 8.66 (s, 1H), 8.43 (m, 2H), 8.38 (d, J=5.7 Hz, 1H), 8.26 (s, 1H), 7.97 (d, J=0.7 Hz, 1H), 7.62 (dd, J=8.8, 2.9 Hz, 1H), 7.28 (d, J=2.4 Hz, 1H), 63.80 (br s, 1H), 6.72 (dd, J=5.7, 2.4 Hz, 1H), 3.85 (s, 3H), 3.35 (m, 2H), 1.12 (t, J=7.2 Hz, 3H); MS (ESI) m/z: 390.2 (M+H+).

Provenance & Evidence