Hydrogen Bromide → HCID 86267820, compound

Participants

Reaction Steps

Using the procedure of Example 6, N-cyclopentyl-4-methoxy-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-2-amine (0.085 g, 0.186 mmol) and HBr (0.085 mL, 0.743 mmol) were combined in acetic acid (2 mL) to afford 2-(cyclopentylamino)-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one (58 mg, 70%). 1H NMR (400 MHz, DMSO-d6): δ 10.78 (br s, 1H), 8.67 (s, 1H), 8.35 (d, J=5.7 Hz, 1H), 8.29-8.23 (m, 2H), 7.96 (s, 1H), 7.50 (d, J=8.6 Hz, 1H), 7.22 (d, J=2.4 Hz, 1H), 6.94 (br s, 1H), 6.60 (dd, J=5.7, 2.4 Hz, 1H), 4.21-4.18 (m, 1H), 3.84 (s, 3H), 2.34 (s, 3H), 1.92-1.89 (m, 2H), 1.68-1.64 (m, 2H), 1.58-1.54 (m, 2H), 1.49-1.40 (m, 2H); MS (ESI) m/z: 444.2 (M+H+).

Provenance & Evidence