反应详情

To a solution of (S)-t-butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (50.0 g) and 2-(3,4-dimethoxyphenoxy)acetic acid (47.8 g) in chloroform (1000 ml), HOBt (35.3 g) and WSC hydrochloride (50.0 g) were added and the mixture was stirred at room temperature for 4 hours. After distilling off the solvent under reduced pressure, water was added, followed by extraction with ethyl acetate. The organic layer was washed successively with saturated aqueous sodium bicarbonate and brine and dried over MgSO4 before it was filtered. The solvent was distilled off under reduced pressure to give a crude form of the titled compound (61.0 g).

1. distillationAfter distilling off the solvent under reduced pressure, water
2. additionwas added
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed successively with saturated aqueous sodium bicarbonate and brine
5. dry with materialdried over MgSO4 before it
6. filtrationwas filtered
7. distillationThe solvent was distilled off under reduced pressure