反应详情

温度

120 °C

To a toluene (700 ml) solution of the compound (61.0 g) obtained in Example 8-(1), Burgess reagent (45.0 g) was added and the mixture was stirred at 120° C. for 4 hours. After adding water to the reaction mixture, the organic layer extracted with AcOEt was dried (Na2SO4), filtered and had the solvent distilled off under reduced pressure; the resulting residue was purified by silica gel chromatography (AcOEt) to give the titled compound (42.0 g).

1. extractionthe organic layer extracted with AcOEt
2. dry with materialwas dried (Na2SO4)
3. filtrationfiltered
4. distillationdistilled off under reduced pressure
5. customthe resulting residue was purified by silica gel chromatography (AcOEt)