HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → (S)-2-((3,4-Dimethoxyphenoxy)methyl)-5-(pyrrolidin-2-yl)-1,3,4-oxadiazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | (S)-t-Butyl 2-(5-((3,4-dimethoxyphenoxy)methyl)-1,3,4-oxadiazol-2-yl)pyrrolidine-1-carboxylate | HCID 86706751 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-2-((3,4-Dimethoxyphenoxy)methyl)-5-(pyrrolidin-2-yl)-1,3,4-oxadiazole hydrochloride | HCID 86706752 | — |
Reaction Steps
To an AcOEt (200 ml) solution of the compound (42.0 g) obtained in Example 8-(2), 4N HCl-AcOEt solution (200 ml) was added and the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure to give a crude form of the titled compound (35.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181229B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-e40d28dc04aa4f218732df29a087f4cd |
| Source note | uspto-grants-2015_11 |