(S)-t-Butyl 2-(5-((3,4-dimethoxyphenoxy)methyl)-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate → (S)-5-((3,4-Dimethoxyphenoxy)methyl)-3-(pyrrolidin-2-yl)-1H-pyrazole

HRID 710057Notes

Reaction equation

HRID 710057 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[O:6][CH2:7][C:8]1[N:12](C)[N:11]=[C:10]([C@@H:14]2[CH2:18][CH2:17][CH2:16][N:15]2C(OC(C)(C)C)=O)[CH:9]=1.COC1C=C(C=CC=1OC)OCC1NN=C([C@@H]2CCCN2C(OC(C)(C)C)=O)C=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[O:6][CH2:7][C:8]1[NH:12][N:11]=[C:10]([C@@H:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)[CH:9]=1

Participants

3

Reactant 2

HCID 86706764(S)-t-Butyl 2-(5-((3,4-dimethoxyphenoxy)methyl)-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-carboxylateHCID 86706769HCID 86706769, compound

Product 1

HCID 86706770(S)-5-((3,4-Dimethoxyphenoxy)methyl)-3-(pyrrolidin-2-yl)-1H-pyrazole

Procedure

The procedure of Example 13-(3) was repeated, except that the compound obtained in Example 13-(2) was replaced by the compound (460 mg) obtained in Example 15-(1); this gave the titled compound (339 mg, pale brown oil.)

Sources & evidence

ORD record
ord-81e5277ec4974a34a84e13b7b0cb395e
Source dataset
uspto-grants-2015_11
Patent number
US09181229B2

Reaction notes

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