Methyl N-(triethylammoniosulfonyl)carbamate → (S)-t-Butyl 2-(5-((3,4-dimethoxyphenoxy)methyl)oxazol-2-yl)pyrrolidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a toluene (10 ml) of the compound (0.250 g) obtained in Example 19-(4), Burgess reagent (0.281 g) was added and the mixture was stirred at 50° C. for 1.5 hours. After reversion to room temperature, the reaction mixture was concentrated to give a crude product, which was further purified by silica gel chromatography (AcOEt/hexane) to give the titled compound (0.156 g, colorless oil.)

Provenance & Evidence