Sodium Carbonate → 6-Bromo-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]thiazole

Participants

Reaction Conditions

Reaction Steps

Intermediate 33 (600 mg, 1.47 mmol) dissolved in DMF (7 ml) and added Na2CO3 (156 mg, 1.47 mmol). This mixture stirred at 110° C. for 17 h. Work up (EtOAc/H2O) afforded the crude. Crude was triturated with Petether and dried to obtain the titled compound (360 mg) as a white solid. 1H-NMR (δ ppm, CDCl3, 400 MHz): 8.71-8.65 (m, 1H), 8.13 (d, J 1.9, 1H), 8.01 (d, J 8.7, 1H), 7.91-7.83 (m, 2H), 7.66 (dd, J 1.9, 8.7, 1H), 3.12 (s, 3H).

Provenance & Evidence