4-Bromo-3-fluorobenzamide → Isopropyl 4-[5-(4-carbamoyl-2-fluorophenyl)benzo[d]oxazol-2-yl]piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-3-fluorobenzamide	HCID 21904775	—
Reactant	Isopropyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2-yl)piperidine-1-carboxylate	HCID 71090092	—
Product	Isopropyl 4-[5-(4-carbamoyl-2-fluorophenyl)benzo[d]oxazol-2-yl]piperidine-1-carboxylate	HCID 71114460	39.2%

Reaction Steps

Following the General Procedure-3, the titled compound (80 mg) was prepared from Intermediate 14 (200 mg, 0.48 mmol) and 4-bromo-3-fluorobenzamide (105 mg, 0.48 mmol) as an off-white solid. M.P.: 194-197° C. MS (m/z): 426.0 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181214B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-f0ae5d38aa884275b07d1314e3be0798
Source note	uspto-grants-2015_11