Benzamide, 4-bromo-2-fluoro-N-methyl- → Isopropyl 4-{5-[3-fluoro-4-(methylcarbamoyl)phenyl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Benzamide, 4-bromo-2-fluoro-N-methyl-	HCID 24694329	—
Reactant	Isopropyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2-yl)piperidine-1-carboxylate	HCID 71090092	—
Product	Isopropyl 4-{5-[3-fluoro-4-(methylcarbamoyl)phenyl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate	HCID 71257242	33.7%

Reaction Steps

Following the General Procedure-3, the titled compound (80 mg) was prepared from Intermediate 14 (200 mg, 0.54 mmol) and 4-bromo-2-fluoro-N-methylbenzamide (200 mg, 0.54 mmol) as a brown solid. M.P.: 116-120° C. MS (m/z): 440.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181214B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-7b7bc5741db448d99687c7f68a2e2ba4
Source note	uspto-grants-2015_11