4-bromo-N-cyclopropyl-2-fluorobenzamide → Isopropyl 4-{5-[4-(cyclopropylcarbamoyl)-3-fluorophenyl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	4-bromo-N-cyclopropyl-2-fluorobenzamide	HCID 9080038	—
Reactant	Isopropyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2-yl)piperidine-1-carboxylate	HCID 71090092	—
Product	Isopropyl 4-{5-[4-(cyclopropylcarbamoyl)-3-fluorophenyl]benzo[d]oxazol-2-yl}piperidine-1-carboxylate	HCID 71257268	7%

Reaction Steps

Following the General Procedure-3, the titled compound (20 mg) was prepared from Intermediate 14 (250 mg, 0.61 mmol) and 4-bromo-N-cyclopropyl-2-fluorobenzamide (156 mg, 0.61 mmol) as an off-white solid. M.P.: 162-165° C. MS (m/z): 466.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181214B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-2163f132f545410ebb4507cac6aa17de
Source note	uspto-grants-2015_11