HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-thiophenecarboxylic acid → HCID 72943814, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Reactant | HCID 90021102 | HCID 90021102 | — |
| Product | HCID 72943814 | HCID 72943814 | 72% |
Reaction Steps
The coupling of (4S,4aR,8aR)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-4a,5,6,7,8,8a-hexahydro-4H-benzo[e][1,3]oxazin-2-ylamine (intermediate XIIIa-2) and 5-chloro-thiophene-2-carboxylic acid (CAS 24065-33-6) following procedure Q yielded the title compound as a white solid (72% yield). MS: m/z=458.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181232B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-d23705e8e2894b8abb2112a0a9e6d8c5 |
| Source note | uspto-grants-2015_11 |