4-Fluorobenzoyl chloride → HCID 89690731, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butyl 2-(3-amino-1H-indazol-6-yl)morpholine-4-carboxylate (43 mg, 0.135 mmol) was dissolved in pyridine (0.2 ml) and the solution was cooled to −5° C. 4-fluorobenzoyl chloride (21.4 mg, 0.135 mmo) was slowly added. After 5 min, the cooling bath was removed and stirring was continuing overnight. The reaction mixture was diluted with ethylacetate (2 ml) and washed with 1M citric acid solution (2 ml). The organic layer was dried over MgSO4 and concentrated in vacuo to give a brown oil which was further purified by flash column chromatography (silica gel, 50% to 100% ethyl acetate in heptane). The product was isolated as a yellow solid (40 mg, 67%), MS (ISP): 441.3 (100%, ([M-tBu+H]+), 385.2 (38%, [M+H]+).

Provenance & Evidence