Hydrochloric Acid → HCID 89690734, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butyl 2-(3-(4-fluorobenzamido)-1H-indazol-6-yl)morpholine-4-carboxylate (40 mg, 0.09 mmol) was dissolved in dioxane (0.2 ml) and a solution of HCl in dioxane (4M, 0.34 ml, 1.36 mmol) was added. The reaction mixture was stirred for 2 h at 60° C. After cooling ether (2 ml) was added, the mixture was stirred for 30 min and the solid was filtered off. It was washed with ether and dried in vacuo to afford 4-fluoro-N-(6-(morpholin-2-yl)-1H-indazol-3-yl)benzamide hydrochloride (22 mg, 66%) as an off-white solid. MS (ISP): 341.2 ([M+H]+).

Provenance & Evidence