1,10-Phenanthroline → HCID 131733933, compound

Participants

Reaction Conditions

Reaction Steps

(R)-tert-Butyl 2-(3-bromo-4-(6-ethoxynicotinamido)phenyl)morpholine-4-carboxylate (100 mg, 0.2 mmol), cesium carbonate (130 mg, 0.4 mmol), 1,10-phenanthroline (3.6 mg, 0.02 mmol), copper(I) iodide (1.9 mg, 0.01 mmol) were mixed together in 1,2-dimethoxyethane (2 ml). The suspension was degassed with Argon and was heated overnight under Argon at 125° C. The mixture was cooled and poured into ethylacetate and filtered. The filtrate was absorbed on silica gel and separated by chromatography (gradient 10% to 50% EtOAc in heptane) to afford an off-white solid (34 mg, 40%). MS (ISP): 426.6 ([M+H]+).

Provenance & Evidence