tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((5-octylisoindolin-2-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step F was substituted for tert-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate in Example 1, Step B, the identical process afforded the title compound in 70% yield. 1H-NMR (CDCl3) 0.86 (tr, 3H, J=6.94 Hz); 1.25 (m, 10H); 1.56 (m, 2H); 2.56 (tr, 2H, J=7.86 Hz); 2.66 (broad m, 4H); 2.89 (s, 2H); 3.57 (s, 4H); 4.07 (s, 4H); 6.98 (s, 1H); 7.0 (d, 1H, J=7.6 Hz); 7.06 (d, 1H, J=7.6 Hz).

Provenance & Evidence