tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((5-((4,6-dichlorobenzofuran-2-yl)methoxy)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step G was substituted for tert-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate in Example 1, Step B, the identical process afforded the title compound in 37% yield, as a off white solid. 1H-NMR (CD3OD) 2.9 (tr, 2H, J=8.2 Hz); 3.37 (tr, 2H, J=8.2 Hz); 3.43-3.53 (m, 4H); 5.0 (s, 2H); 6.5 (d, 1H, J=8.4 Hz); 6.65-6.7 (m, 1H); 6.76 (s, 2H); 7.19 (d, 1H, J=1.5 Hz); 7.37 (m, 1H).

Provenance & Evidence