tert-Butyl 2,2-dimethyl-5-((5-octylisoindolin-2-yl)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((6-octyl-3,4-dihydroquinolin-1(2H)-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step D is substituted for tert-butyl 2,2-dimethyl-5-((5-octylisoindolin-2-yl)methyl)-1,3-dioxan-5-ylcarbamate in Example 2, Step G, the identical process afforded the title compound in 36% yield., as a colourless solid. 1H-NMR (CDCl3) 0.86 (tr, 3H, J=7 Hz); 1.26 (m, 10H); 1.53 (m, 2H); 1.92 (m, 2H); 2.22 (broad s, 4H+H2O); 2.43 (tr, 2H, J=8 Hz); 2.76 (tr, 2H, J=6.4 Hz); 3.23 (s, 2H); 3.26 (tr, 2H, J=3.7 Hz); 3.51-3.61 (m, 4H); 6.7-6.87 (m, 3H).

Provenance & Evidence