tert-Butyl 2,2-dimethyl-5-((5-octylisoindolin-2-yl)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((6-octyl-3,4-dihydroisoquinolin-2(1H)-yl)methyl) propane-1,3-diol

Participants

Reaction Steps

When the product of Step F is substituted for tert-butyl 2,2-dimethyl-5-((5-octylisoindolin-2-yl)methyl)-1,3-dioxan-5-ylcarbamate in Example 2, Step G, the identical process afforded the title compound in 68% yield., as a colourless solid. 1H-NMR (CDCl3) 0.86 (tr, 3H, J=6.9 Hz); 1.26 (m, 10H); 1.54 (m, 2H); 2.48-3 (m, 3H); 3.54 (s, 4H); 3.76 (s, 2H); 6.7 p-7.06 (m, 3H).

Provenance & Evidence