反应详情

The product of Step C was dissolved in anhydrous dioxane (20 ml) and to it MnO2 (0.5 g) was added. The suspension was stirred at reflux for 6 h and then filtered through Celite. The filtrate was distilled off and the residue was purified by FCC (SiO2) to give the product (0.18 g; 89%), as creamy paste. 1H-NMR (CDCl3) 3.24 (s, 1H); 7.15 (tr, 2H, J=8.73 Hz); 7.60 (d, 2H, J=6.69 Hz); 7.71 (d, 2H, J=6.58 Hz); 7.78-7.84 (m, 2H).

1. additionwas added
2. temperatureat reflux for 6 h
3. filtrationfiltered through Celite
4. distillationThe filtrate was distilled off
5. customthe residue was purified by FCC (SiO2)
6. customto give the product (0.18 g; 89%)